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Postmarketing surveillance has reported cases of severe hepatic reactions, including liver necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure.
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Some of these reported cases resulted in fatalities or liver transplantation. Physicians should measure transaminases periodically in patients receiving long-term therapy cataflam diclofenac. Based on clinical trial data and postmarketing experiences, transaminases should be monitored within 4 to 8 week after initiating treatment with diclofenac.
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Consequently, the same precautions regarding renal risk that are followed for nonselective NSAIDs should be used when selective COX-2 inhibitors are administered. Studies in Pakistan showed diclofenac caused acute kidney failure in vultures when they ate the carcasses of animals that had recently been treated with it. Drug-sensitive species and individual humans are initially assumed to lack 50mg expressing specific drug detoxification enzymes. These symptoms are rare, but exist in significant enough numbers to include as potential side effects.
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Blockage of voltage-dependent sodium channels after activation of the channel, diclofenac inhibits its reactivation also known as phase inhibition [ citation needed ] Blockage of acid-sensing ion prices ASICs [28] Positive allosteric modulation of KCNQ- and BK-potassium channels diclofenac opens these channels, cataflam 50mg price, leading to hyperpolarization of the cell membrane [ citation needed ] Main article: The mechanism is presumed to be renal failure[30] however cataflam may be due to direct inhibition of uric acid secretion in vultures.
At a meeting of the National Wildlife Board in Marchcataflam 50mg price, the Government of India announced it intended to phase out the veterinary use of diclofenac. In many places, populations of feral dogs Canis familiaris have increased sharply from the disappearance of Gyps vultures as the main scavenger of 50mg and domestic ungulate carcasses.