Metronidazole bp 500mg - metronidazole (Flagyl, Flagyl ER) Antibiotic
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Metronidazole inhibits metabolism of phenytoin increases plasma-phenytoin concentration. Metronidazole inhibits metabolism of fluorouracil. Metronidazole is contraindicated in the first trimester see section 4, metronidazole bp 500mg.
For all other indications Metronidazole should metronidazole be used if the benefits 500mg the risks or no other alternative is available especially in amoxil 200mg for dogs first trimester. It is advisable to stop breast feeding until 12 - 24 hours after Metronidazole therapy has been discontinued when single high doses have been used see section 4, metronidazole bp 500mg.
Serious adverse reactions occur rarely with standard recommended regimens. If you are elderly or have liver disease, it is particularly important to take this medicine exactly as directed by the doctor. If you take more than you should If you or someone else swallow a lot of tablets at the same time, or you think a child may have swallowed any contact your nearest hospital casualty department or tell your doctor immediately, metronidazole bp 500mg.
Signs of an overdose include feeling or being sick, loss of appetite, diarrhoea, metallic taste, metronidazole bp 500mg, headache, dizziness, insomnia or drowsiness. If you forget to take the tablets Do not take a double dose to make up for a 500mg dose. If you metronidazole to take a dose take it as 500mg as you remember it and then metronidazole the next dose at the right time, metronidazole bp 500mg.
If you stop taking the tablets If you stop taking the tablets your infection may come back.
Talk 500mg your doctor before you stop taking the tablets metronidazole follow their advice. Please tell your doctor or pharmacist if you notice any of the following effects or any effects not listed. Contact your doctor at once if you notice any of the following side metronidazole Tell your 500mg if you notice any of the following side effects or notice any other effects not listed: Very rare less than 1 in 10, users: You should tell your doctor who might want you to have a blood test mental health problems including hallucinations seeing or hearing things that are not theredrowsiness, dizziness, fits, tingling, pain or a feeling of weakness in the arms or legs, metronidazole bp 500mg, numbness Encephalopathy headaches, light sensitivity, metronidazole bp 500mg, confusion, fever, paralysis, stiff neck Cerebellar syndrome poor co-ordination or muscle control, involuntary shakiness, uncontrolled eye movements, metronidazole bp 500mg, speech disorders, walking abnormally double vision, short sightedness changes in liver function tests, metronidazole bp 500mg, jaundice yellowing of the skin or whites of amoxil 200mg for dogs eyesmetronidazole bp 500mg, inflammation of the pancreas pancreatitis causing very severe abdominal painflushing skin rashes, metronidazole bp 500mg, itching, small pus-containing blisters, muscles and joint pain, darkening of the urine Not known cannot be estimated from the available data: Adults- mg t.
Children- years mg t. Duration Days or 2days ; For Tablet: Duration 3 Days; Metronidazole Tablet: Adults- 2 g once daily; Children- years 1g once daily; years mg once daily; years mg once daily. Duration 7 Days; For Tablet: Adults- 2 g single dose; For Suspension: Postoperative metronidazole infection specially in operation abdominal or gynecological surgery: Adults- mg b. Patients should be monitored for adverse reactions, such as peripheral or central neuropathy e.
Metronidazole should be used with caution in patients with active or chronic severe peripheral and central nervous system disease due to the risk of neurological aggravation.
There is a possibility that after 500mg vaginalis has been eliminated 500mg gonococcal infection might be persistant, metronidazole bp 500mg. The half-life elimination of metronidazole remains the same in patients with renal failure, therefore there is no needs for dose reduction.
However, such patients retain the metabolites of metronidazole, the clinical significance of this is not known. In patients undergoing haemodialysis metronidazole and its metabolites are efficiently removed during an eight hour dialysis period.
Therefore, metronidazole bp 500mg, Metronidazole should be re-administered immediately after haemodialysis. No adjustment in the dosage of Metrolyl is required in patients with renal failure undergoing intermittent peritoneal metronidazole IDP or continuous ambulatory peritoneal dialysis CAPD.
Laboratory Tests Metronidazole is a nitroimidazole and should be used with 500mg in patients with evidence of or history of blood dyscrasia, metronidazole bp 500mg.
A mild 500mg has been observed during its administration; however, no persistent hematologic abnormalities attributable to metronidazole have been observed in clinical studies.
Total and differential leukocyte counts are recommended before and after therapy for trichomoniasis and amebiasis, especially if a second course of therapy is necessary, and before metronidazole after therapy for anaerobic infections. Drug Interactions Metronidazole has been reported to potentiate the anticoagulant effect of warfarin and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time.
This possible drug interaction should be considered when metronidazole is prescribed for patients on this type of anticoagulant therapy. The simultaneous administration of drugs that induce microsomal liver enzymes, metronidazole bp 500mg, such as phenytoin or phenobarbital, may accelerate the elimination of metronidazole, resulting in reduced plasma levels; impaired clearance of phenytoin has also been reported.
The simultaneous metronidazole of drugs that decrease microsomal liver enzyme activity, such as cimetidine, may prolong the half life and decrease plasma clearance of metronidazole. In patients stabilized on relatively high doses of lithium, short term metronidazole therapy has been associated with elevation of serum lithium and, in a few cases, signs of lithium toxicity.
Serum lithium and serum creatinine levels should be obtained several days after beginning metronidazole to detect any increase that may precede clinical symptoms of lithium intoxication. Alcoholic beverages should not be consumed during metronidazole therapy and for at least one day afterward because 500mg cramps, nausea, vomiting, headaches, and flushing may occur, metronidazole bp 500mg.
Psychotic reactions have been reported in alcoholic patients who are using metronidazole and disulfiram concurrently.
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Metronidazole should not be given to patients who have taken disulfiram within the last two weeks. Values of zero may be observed. Interference is due metronidazole the similarity in absorbance peaks of NADH nm and metronidazole nm at pH 7.
Carcinogenesis, Mutagenesis, Impairment of Fertility Metronidazole has shown evidence of carcinogenic activity in a number of studies involving chronic, oral administration in mice and rats. Prominent among the effects in the mouse was the promotion of 500mg tumorigenesis.
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This has been 500mg in all six reported studies in that species, including one study in which the animals were dosed on an intermittent schedule administration during every fourth week only.
At very high dose levels approx. Also, the published results 500mg one of the mouse studies indicate an increase in the incidence of malignant lymphomas as well as pulmonary neoplasms associated 500mg lifetime feeding of the drug, metronidazole bp 500mg. All these effects are statistically significant. Several long-term, oral-dosing studies in the rat have been completed.
There were statistically significant increases in the incidence of various neoplasms, particularly in mammary and hepatic tumors, among female rats administered metronidazole over those noted in the concurrent female control groups, metronidazole bp 500mg.
Two lifetime tumorigenicity studies in hamsters have been performed and reported to be negative. Although metronidazole has shown mutagenic activity in 500mg number of in vitro assay systems, metronidazole bp 500mg, studies metronidazole mammals metronidazole vivo have metronidazole to demonstrate a potential for genetic damage.
Fertility studies have been performed in mice at doses up to six times the maximum recommended human dose based on mg per sq. Pregnancy Teratogenic Effects Metronidazole category B Metronidazole crosses the placental barrier and enters the fetal circulation rapidly, metronidazole bp 500mg.
Reproduction studies have been performed in rats at doses up to five times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to metronidazole. The relationship of these findings to the drug is unknown.